Built by a practising gastroenterologist

From symptoms
to a safe, signed
plan.

Cognition Boxes forces clinical AI through seven transparent, non-skippable steps — with deterministic safety checks, a mandatory clinician gate and a tamper-evident audit trail.

  • No login
  • No patient data stored
  • Deterministic safety core
RUN CB-7Q2X9K · Septic shock, CAP
01Analyze…
02Synthesize
03Reason
04Guideline Align
05Safety
06Human Gate
07Patient Explain
MODIFYAzithromycin → doxycycline (QTc 478 ms + citalopram) · Hold metformin, lisinopril
0Governed boxes
0Specialties
0Symptoms
0Red flags
0Workup rules
ESC ACS 2023✦Surviving Sepsis 2021✦ATS/IDSA CAP 2019✦ACG UGIB 2021✦ESGE 2021✦ACG Pancreatitis 2024✦ADA/EASD/JBDS 2024✦ESC AF 2024✦KDIGO AKI 2012✦UKKA Hyperkalaemia 2023✦Baveno VII✦NICE✦BSG✦WGO✦ESC ACS 2023✦Surviving Sepsis 2021✦ATS/IDSA CAP 2019✦ACG UGIB 2021✦ESGE 2021✦ACG Pancreatitis 2024✦ADA/EASD/JBDS 2024✦ESC AF 2024✦KDIGO AKI 2012✦UKKA Hyperkalaemia 2023✦Baveno VII✦NICE✦BSG✦WGO✦
● New

Structured history

Tap symptoms from 31 specialties, tick each red flag present or absent, and the boxes do the rest — red flags escalate the safety verdict, negatives are documented, and guideline-referenced workup lands in the plan.

Try it now →
Dysphagia
Progressive courseAge over 45HaematemesisIron deficiency anaemiaUnable to swallow salivaNeck lumpSmoker / alcohol use
→ Urgent: upper GI endoscopy with biopsies · ACG / BSG
See it in action

Your complete workflow

From raw intake to a signed plan and a patient leaflet — every step visible, every step sealed.

STEP 1 / 7
01

Analyze

Perception & normalisation

Vitals, labs, notes, ECG and imaging text and medications are ingested. Units are converted (µmol/L ↔ mg/dL, mmol/L ↔ mg/dL), negations understood (“no fever”), implausible values flagged as input drift.

Unit normalisationNLP with negationInput-drift monitor
Key feature 01 — Safety

Deterministic
safety core

Doses, interactions, renal limits, allergies and cumulative QT are checked by rules you can read — never by a model guessing. Same input, same verdict, every time.

PROCEEDNew AF · CHA₂DS₂-VA 3 · apixaban 5 mg BD
MODIFYNSTEMI · CrCl 21 → enoxaparin once daily
HALTDKA · K 3.1 → insulin held until K ≥ 3.5
Key feature 02 — Adaptive

Boxes that
insert themselves

Missing creatinine? A Data Completion box appears. Notes say “afebrile” but the thermometer says 39.2 °C? Contradiction Resolution locks the verdict to HALT. Shock physiology? Enhanced Safety applies sick-day rules.

11b22b3455b67

Dashed boxes are inserted at run time by the Adaptive Cognition Pathway Engine.

Key feature 03 — Human gate

Zero AI
autonomy

A named clinician accepts, modifies or rejects every plan with a reason code. Only then are FHIR R4 orders produced. Overrides are tracked to learn where humans and machine disagree.

✓ Accept
✎ Modify
✕ Reject
{ "resourceType": "MedicationRequest",
  "status": "active",
  "medication": "Doxycycline",
  "dosage": "100 mg IV every 12 h",
  "note": "authorised by Dr A. Clinician" }
Key feature 04 — Audit vault

Tamper-evident
by design

Every box seals a SHA-256 hash of its output into a linked, HMAC-sealed chain. Change one character after the fact and verification fails — the gate refuses to sign an altered run.

intakedb65f4…
box1a25097…
box27f266c…
box3a0a6a3…
box41ac373…
box50a38cf…
box6e11e27…
box71c5b87…

✕ Entry 5 altered after sealing — chain broken.

Key feature 05 — Structured history

678 symptoms.
3,849 red flags.

Build a history in taps across 31 specialties. Every symptom carries its own red-flag checklist; present flags escalate the verdict, absent ones become pertinent negatives, and 1,533 guideline-referenced rules suggest the workup.

Dysphagia
Progressive courseAge over 45HaematemesisIron deficiency anaemiaUnable to swallow salivaNeck lumpSmoker / alcohol use
→ Urgent: upper GI endoscopy with biopsies · ACG / BSG
All features

Everything governed clinical AI needs

7 + 3 boxes

Seven fixed steps and three adaptive inserts — Data Completion, Contradiction Resolution, Enhanced Safety.

678 symptoms · 3,849 red flags

Across 31 specialties, from gastroenterology to neonatology, each symptom with its own checklist.

1,533 workup rules

Guideline-referenced investigations and management.

612 generic drugs

Formulary notes for medicines outside the interaction engine.

Validated scores

qSOFA, CURB-65, Glasgow-Blatchford, CHA₂DS₂-VA, CKD-EPI 2021, Cockcroft-Gault, KDIGO staging.

Cumulative QT

Baseline QTc plus every QT-prolonging drug, current and planned.

FHIR R4 orders

Only clinician-approved actions become MedicationRequest and ServiceRequest resources.

Model-agnostic

Any LLM or vision model can plug in and inherit the governance.

Privacy by design

Stateless server; runs stay in the clinician’s browser.

Designed for

One architecture. Every stakeholder.

Hospitals

Standardised, auditable decision support with reduced medico-legal exposure.

Clinicians

Transparent reasoning you can inspect, override and sign — in minutes.

Health-AI vendors

Route your model through the boxes to inherit safety, oversight and audit.

Regulators & auditors

A complete, verifiable record of every input, rule, verdict and human decision.

“The hard problems in clinical AI aren’t the models. They’re oversight and safe deployment at the workflow level.”
Dr Jose MathewMD, DM (Gastroenterology), MRCP (UK) · Inventor, Cognition Boxes™ · Founder, Doctoredge Innovations
FAQ

Got questions?

Not yet. This is a research demonstrator of a patent-pending governance architecture. It is designed to align with the EU AI Act and to follow the FDA SaMD pathway, but it has not been assessed or cleared by any regulator and must not be used for real patient care.

Your clinical AI.
Governed. In minutes.

Open the live console →

Partnerships, pilots and investment: doctoredgeinnovations@gmail.com

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